Enrollment

Study Enrollment Projections by Region

	North-Central Uganda		Northwestern Uganda		Northern Tanzania		Western Kenya
	Attend	Enroll	Attend	Enroll	Attend	Enroll	Attend	Enroll
Accrual Year 1	150	75	50*	25	NA		NA
Accrual Year 2	150	98	100	65	125*	81	100*	65
Accrual Year 3	150	113	100	75	250	188	200	150
Accrual Year 4	150	135	100	90	250	225	200	180
TOTAL	600	420	350	255	625	494	500	395

North-Central Uganda

	Attend	Enroll
Accrual Year 1	150	75
Accrual Year 2	150	98
Accrual Year 3	150	113
Accrual Year 4	150	135
TOTAL	600	420

Northwestern Uganda

	Attend	Enroll
Accrual Year 1	50*	25
Accrual Year 2	100	65
Accrual Year 3	100	75
Accrual Year 4	100	90
TOTAL	350	255

Northern Tanzania

	Attend	Enroll
Accrual Year 1	NA
Accrual Year 2	125*	81
Accrual Year 3	250	188
Accrual Year 4	250	225
TOTAL	625	494

Western Kenya

	Attend	Enroll
Accrual Year 1	NA
Accrual Year 2	100*	65
Accrual Year 3	200	150
Accrual Year 4	200	180
TOTAL	500	395

We project that the study will accrue 409 cases by end of year 2 and 900 cases by end of year three, assuming 70% average enrollment.

* Enrollment will be slow in the first year of the study at each site, but should improve thereafter.