• Participants of the EMBLEM study status update, staff meeting, and cancer research methods workshop in Mwanza, Tanzania.

    Participants of the EMBLEM study status update, staff meeting, and cancer research methods workshop in Mwanza, Tanzania.

  • Closing session at the EMBLEM staff meeting in Mwanza, Tanzania.

    Closing session at the EMBLEM staff meeting in Mwanza, Tanzania.

  • EMBLEM staff at AORTIC, December 2011, Cairo, Egypt.

    EMBLEM staff at AORTIC, December 2011, Cairo, Egypt.

  • Charles Isabirye and Ronnie Ogwang who designed the EMBLEM posters and BL tutorial.

    Charles Isabirye and Ronnie Ogwang who designed the EMBLEM posters and BL tutorial.

  • Draft EMBLEM posters developed by Charles Lsabirye and Ronnie Ogwang.

    Draft EMBLEM posters developed by Charles Lsabirye and Ronnie Ogwang.

  • Dr. Tobias Kinyera enrolling a control in northern Uganda.

    Dr. Tobias Kinyera enrolling a control in northern Uganda.

  •  A Community Advisory Board tour the BL ward in Lacor Hospital with Dr. Martin Ogwang, co-PI.

    A Community Advisory Board tour the BL ward in Lacor Hospital with Dr. Martin Ogwang, co-PI.

  • Dr. Moses Joloba and Mr. Samuel Kirimunda, EMBLEM study monitors, with Dr. Sam Mbulaiteye, PI, conducting a site visit in Bugando Medical Centre.

    Dr. Moses Joloba and Mr. Samuel Kirimunda, EMBLEM study monitors, with Dr. Sam Mbulaiteye, PI, conducting a site visit in Bugando Medical Centre.

  • EMBLEM poster in Swahili at Bugando Medical Centre.

    EMBLEM poster in Swahili at Bugando Medical Centre.

  • William Aketch, Dr. Peter Odada and Mediatrix Mumia discussing sample storage in the EMBLEM laboratory at Homabay, Kenya.

    William Aketch, Dr. Peter Odada and Mediatrix Mumia discussing sample storage in the EMBLEM laboratory at Homabay, Kenya.

TRAINING FOR PRINCIPAL INVESTIGATORS: Fogarty International Center (FIC) conducted a Principal Investigator (PI) Workshop in September 2014 at Kisumu, Kenya. FIC and the Centre for the AIDS Programme of Research in South Africa (CAPRISA) are sponsoring a two-week follow-up component in South Africa. Applications for this supported follow-up component are due January 15, 2015.

The National Cancer Institute (NCI) is conducting a multicountry and multiyear case-control study of childhood Burkitt’s lymphoma in Uganda, Tanzania and Kenya. The study, entitled Epidemiology of Burkitt’s Lymphoma in East-African Children and Minors (EMBLEM), will evaluate the role of:

  1. Repeated malaria infections in endemic Burkitt’s lymphoma,
  2. Malaria genetic variants in Burkitt’s lymphoma,
  3. Epstein-Barr virus (EBV) genetic variants in Burkitt’s lymphoma.

The specific hypotheses that will be tested are, whether:

  • Carriage of genetic markers that increase resistance to malaria is associated with decreased risk of Burkitt’s lymphoma.
  • Certain EBV genetic variants are associated with increased risk for Burkitt’s lymphoma.

In addition, the study will generate a unique data and sample repository to allow for novel study exploration into the etiology and biology of the disease, including the use of genome-wide scans.

To learn more about EMBLEM and Burkitt lymphoma, watch our video.