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Epidemiological Studies
Primary Goals
- Investigate age-specific patterns of BL to determine whether the risk of eBL increases monotonically with age or is heterogenous, consistent with etiologies of BL that vary age-specifically;
- Investigate the correlation between BL risk and Pf prevalence, density, or parasite genetic diversity (swarm pattern) to discover the malaria biomarker that is predictive of BL;
- Investigate the distribution of key risk factors, such as malaria prevalence, to generate hypotheses that can be tested in analytic studies.
Epidemiologic studies of BL are designed to provide insights about who is at risk of BL, where they live, when they get BL, how they present clinically, and why they are at increased risk of BL. These epidemiologic studies are conducted in population-based datasets to generate hypotheses that can be evaluated in hypothesis driven studies. In rare instances, we conduct studies focused on measuring the burden and distribution of key risk factors of endemic Burkitt Lymphoma (eBL), such as the prevalence, burden and intensity of malaria in eBL endemic regions.
Publications
- Burkitt Lymphoma
- Burkitt Lymphoma Incidence in Five Continents
- Inverse association of falciparum positivity with endemic Burkitt lymphoma is robust in analyses adjusting for pre-enrollment malaria in the EMBLEM case-control study
- Endemic Burkitt lymphoma: a complication of asymptomatic malaria in sub-Saharan Africa based on published literature and primary data from Uganda, Tanzania, and Kenya
- Risk factors for Burkitt lymphoma in East African children and minors: A case-control study in malaria-endemic regions in Uganda, Tanzania and Kenya
- A Cross-Sectional Population Study of Geographic, Age-Specific, and Household Risk Factors for Asymptomatic Plasmodium falciparum Malaria Infection in Western Kenya
- A cross-sectional study of asymptomatic Plasmodium falciparum infection burden and risk factors in general population children in 12 villages in northern Uganda
- Age-related heterogeneity of Burkitt lymphoma
- Age and geographic patterns of Plasmodium falciparum malaria infection in a representative sample of children living in Burkitt lymphoma-endemic areas of northern Uganda.
- International long-term trends and recent patterns in the incidence of leukemias and lymphomas among children and adolescents ages 0-19 years
- Medical history, lifestyle, family history, and occupational risk factors for sporadic Burkitt lymphoma/leukemia: the Interlymph Non-Hodgkin Lymphoma Subtypes Project
- Burkitt lymphoma risk in U.S. solid organ transplant recipients
- Incidence and trends in Burkitt lymphoma in northern Tanzania from 2000 to 2009.
- Pediatric, elderly, and emerging adult-onset peaks in Burkitt's lymphoma incidence diagnosed in four continents, excluding Africa
- Trimodal age-specific incidence patterns for Burkitt lymphoma in the United States, 1973-2005
- Sporadic childhood Burkitt lymphoma incidence in the United States during 1992-2005
- Incidence and geographic distribution of endemic Burkitt lymphoma in northern Uganda revisited